THE INNOVATIONS, ADVANCES AND OUTLOOKS OF LIQUID BIOPSY IN ONCOLOGY: A LITERATURE REVIEW

Barra lateral de artigos

PDF (English)
Publicado: jul 6, 2018
DOI: https://doi.org/10.14295/aimj.v2i4.38

Conteúdo do artigo principal

Antonio Marlos Duarte de Melo
Federal University of Ceará, Brasil
Messias Silvano da Silva Filho
Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.
Bárbara Torquato Alves
Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.
Kevellyn Cruz Aguilera
Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.
Ana Maria Correia Alencar
Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.
Ana Maria Lima Carneiro de Andrade
Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.
Daniel Gonçalves Leite
Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.
Ricardo Souto Quidute
Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Resumo

Studies on the biology of cancer are multiplying and have been giving significant repercussions on the care of cancer patients, and there is a growing need to evaluate the biology of the tumor. Conventional tissue biopsies currently represent the gold standard in the diagnosis of cancer, but they are not suitable for serial analysis because of the need for invasive procedures, besides being able to present a high risk of life and also impossibility of reaching surgical in some tumors. To solve this obstacle, the use of the Liquid Biopsy, which analyzes the presence of biomarkers released by cancer cells, such as circulating tumor cells (CTCs), tumor cell DNA (ctDNA) and exosomes is being discussed. These techniques are non-invasive or minimally invasive and collect their samples from peripheral blood, plasma and serum, urine, saliva and cerebrospinal fluid (CSF). As they are already being used in the treatment of several histopathological types of cancer, these new techniques generally represent a revolution in the understanding of early diagnosis, choice of personalized treatment, follow-up of the treatment response in real time, detection of minimal residual disease and prognosis for malignant neoplasms. The objective of this study was to present a literature review to clarify the fundamental molecular and clinical aspects involved in this revolutionary diagnostic technique by extracting the data from the sample.

 

Keywords: Liquid Biopsy. Oncology.: literature review

Métricas

Carregando Métricas ...

Detalhes do artigo

Como Citar
Melo, A. M. D. de, Silva Filho, M. S. da, Alves, B. T., Aguilera, K. C., Alencar, A. M. C., Andrade, A. M. L. C. de, Leite, D. G., & Quidute, R. S. (2018). THE INNOVATIONS, ADVANCES AND OUTLOOKS OF LIQUID BIOPSY IN ONCOLOGY: A LITERATURE REVIEW. Amadeus International Multidisciplinary Journal, 2(4), 117–128. https://doi.org/10.14295/aimj.v2i4.38
Edição
v. 2 n. 4 (2018)
Seção
Review article

Esta licença permite que os reutilizadores distribuam, remixem, adaptem e construam sobre o material em qualquer meio ou formato apenas para fins não comerciais e apenas enquanto a atribuição for dada ao criador. 

Biografia do Autor

Antonio Marlos Duarte de Melo, Federal University of Ceará, Brasil

Professora Adjunta.

Messias Silvano da Silva Filho, Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

 Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Bárbara Torquato Alves, Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Kevellyn Cruz Aguilera, Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Ana Maria Correia Alencar, Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Ana Maria Lima Carneiro de Andrade, Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Daniel Gonçalves Leite, Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Ricardo Souto Quidute, Faculty of Medicine Estacio of Juazeiro do Norte (Estacio-FMJ), Juazeiro do Norte, Ceara, Brazil.

Institute of Mama of Cariri, Juazeiro do Norte, Ceara, Brazil.


Referências

Astaras, C. et al. [Liquid biopsy, a new opportunity for personalized oncology]. Revue Médicale Suisse, v. 14, n. 607, p.1028-1032, 16 maio 2018.

Hwang, William L.; Pleskow, Haley M.; Miyamoto, David T.. Molecular analysis of circulating tumors cells: Biomarkers beyond enumeration. Advanced Drug Delivery Reviews, v. 125, p.122-131, fev. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.addr.2018.01.003.

Yoneda, Kazue et al. A liquid biopsy in primary lung cancer. Surgery Today, p.1-14, 11 abr. 2018. Springer Nature. http://dx.doi.org/10.1007/s00595-018-1659-2.

Babayan, Anna; Pantel, Klaus. Advances in liquid biopsy approaches for early detection and monitoring of cancer. Genome Medicine, v. 10, n. 1, p.1-3, 20 mar. 2018. Springer Nature. http://dx.doi.org/10.1186/s13073-018-0533-6.

Tadimety, Amogha et al. Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis. Critical Reviews In Clinical Laboratory Sciences, v. 55, n. 3, p.140-162, fev. 2018. Informa UK Limited. http://dx.doi.org/10.1080/10408363.2018.1425976.

Gorgannezhad, Lena et al. Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies. Lab On A Chip, v. 18, n. 8, p.1174-1196, 2018. Royal Society of Chemistry (RSC). http://dx.doi.org/10.1039/c8lc00100f.

Morrison, Gareth J.; Goldkorn, Amir. Development and Application of Liquid Biopsies in Metastatic Prostate Cancer. Current Oncology Reports, v. 20, n. 4, p.1-10, 23 mar. 2018. Springer Nature. http://dx.doi.org/10.1007/s11912-018-0683-0.

Nonaka, T.; Wong, D.t.w.. Liquid Biopsy in Head and Neck Cancer: Promises and Challenges. Journal Of Dental Research, v. 97, n. 6, p.701-708, 7 mar. 2018. SAGE Publications. http://dx.doi.org/10.1177/0022034518762071.

Todenhöfer, Tilman et al. Liquid Biopsy-Analysis of Circulating Tumor DNA (ctDNA) in Bladder Cancer. Bladder Cancer, v. 4, n. 1, p.19-29, 20 jan. 2018. IOS Press. http://dx.doi.org/10.3233/blc-170140

Liu, Chang; Yang, Yunchen; Wu, Yun. Recent Advances in Exosomal Protein Detection Via Liquid Biopsy Biosensors for Cancer Screening, Diagnosis, and Prognosis. The Aaps Journal, v. 20, n. 2, p.1-13, mar. 2018. American Association of Pharmaceutical Scientists (AAPS). http://dx.doi.org/10.1208/s12248-018-0201-1.

Stewart, Caitlin M et al. The value of cell-free DNA for molecular pathology. The Journal Of Pathology, v. 244, n. 5, p.616-627, 12 mar. 2018. Wiley. http://dx.doi.org/10.1002/path.5048.

Franchino, Federica; Rudà, Roberta; Soffietti, Riccardo. Mechanisms and Therapy for Cancer Metastasis to the Brain. Frontiers In Oncology, v. 8, p.1-28, 24 maio 2018. Frontiers Media SA. http://dx.doi.org/10.3389/fonc.2018.00161.

Yao, Nu et al., E. M. (2018). Structure and function analysis in circulating tumor cells: using nanotechnology to study nuclear size in prostate cancer. American Journal of Clinical and Experimental Urology, 6(2), 43–54.

Stewart, Caitlin M.; Tsui, Dana W.y.. Circulating cell-free DNA for non-invasive cancer management. Cancer Genetics, p.1-40, mar. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.cancergen.2018.02.005.

Rohanizadegan, Mersedeh. Analysis of circulating tumor DNA in breast cancer as a diagnostic and prognostic biomarker. Cancer Genetics, p.1-10, fev. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.cancergen.2018.02.002.

Torres, Carolina; Grippo, Paul J.. Pancreatic cancer subtypes: a roadmap for precision medicine. Annals Of Medicine, v. 50, n. 4, p.277-287, 22 mar. 2018. Informa UK Limited. http://dx.doi.org/10.1080/07853890.2018.1453168.

Halvaei, Sina et al. Exosomes in Cancer Liquid Biopsy: A Focus on Breast Cancer. Molecular Therapy - Nucleic Acids, v. 10, p.131-141, mar. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.omtn.2017.11.014.

Wu, Shang-gin et al. Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer. Molecular Cancer, v. 17, n. 1, p.1-14, 19 fev. 2018. Springer Nature. http://dx.doi.org/10.1186/s12943-018-0777-1.

Gootenberg, Jonathan S. et al. Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6. Science, v. 360, n. 6387, p.439-444, 15 fev. 2018. American Association for the Advancement of Science (AAAS). http://dx.doi.org/10.1126/science.aaq0179.

Li, Ting-ting et al. Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells. World Journal Of Gastroenterology, v. 24, n. 21, p.2236-2246, 7 jun. 2018. Baishideng Publishing Group Inc.. http://dx.doi.org/10.3748/wjg.v24.i21.2236.

Kaiser, Jocelyn. ‘Liquid biopsy’ for cancer promises early detection. Science, v. 359, n. 6373, p.259-259, 18 jan. 2018. American Association for the Advancement of Science (AAAS). http://dx.doi.org/10.1126/science.359.6373.259.

Ilie, Marius et al. “Sentinel” Circulating Tumor Cells Allow Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease. Plos One, v. 9, n. 10, p.1-7, 31 out. 2014. Public Library of Science (PLoS). http://dx.doi.org/10.1371/journal.pone.0111597.