HEMORRHAGIC NEUROLOGICAL MANIFESTATIONS IN A PATIENT WITH COVID - 19: CASE REPORT
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Abstract: SARS-CoV-2 infection has had a major impact on global health, affecting from the respiratory system to the central nervous system, generating a wide spectrum of clinical manifestations. Stroke has been reported in the recent literature when addressing the neurological repercussions in patients affected by COVID-19, with unfavorable outcomes when compared to those not infected by SARS-CoV-2. There are multiple theories that try to elucidate neural clinical manifestations, from hematogenous infection to direct entry through the cribiform blade. This article shows a case report of a patient with COVID-19 and neurological involvement with diagnostic hypotheses of acute necrotizing encephalopathy, a rare post-viral infection condition in adults and ischemic stroke with subsequent hemorrhagic transformation, correlating the aspects observed in the image and in the patient's clinic with the current literature and theories.
Keywords: Coronavirus infections, Acute necrotizing encephalopathy, Hemorrhagic transformation, Ischemic stroke.
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Referências
Ackermann, M., Verleden, S. E., Kuehnel, M., Haverich, A., Welte, T., Laenger, F., Vanstapel, A., Werlein, C., Stark, H., Tzankov, A., Li, W. W., Li, V. W., Mentzer, S. J., & Jonigk, D. (2020). Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. New England Journal of Medicine. DOI: https://doi.org/10.1056/nejmoa2015432
Akçai, S., Ozlu, T., Yilmaz, A. (2020). Radiological approaches to COVID-19 pneumonia. Turkish Journal of Medical Sciences, 50(3), 604-610. DOI: 10.3906/sag-2004-160
Akin, P. T., Belko, J., Uyeki, T. M., Axelrod, Y., Lee, K. K., & Silvertthorn, J. (2020). H1N1 Encephalitis Malignant Edema and Review of Neurological Complications of Influenza. Disponível: https://link.springer.com/article/10.1007%2Fs12028-010-9436-0. Acesso em: 04 ago. 2020.
Arabi, Y. M. et al. (2020). Severe Neurologic Syndrome Associed With Middle East Respiratory Syndrome Corona Virus(MERS-CoV). 20 jan 2020. Springer Science and Business Media LLC. Disponível em: https://link.springer.com/article/10.1007%2Fs15010-015-0720-y. Acesso em: 06 de jun 2020.
Baig, A. M. (2020). Neurological Manifestations in COVID‐19 Caused by SARS-CoV-2. Cns Neuroscience & Therapeutics. Disponível em http://dx.doi.org/10.1111/cns.13372. Acesso em: 09 jun. 2020
Benussi, A. et al. (2020) Clinical Characteristics and Outcomes of Inpatients With Neurologic Disease and COVID-19 in Brescia, Lombardy, Italy. Neurology. Ovid Technologies (Wolters Kluwer Health). Disponível em: https://n.neurology.org/content/early/2020/05/22/WNL.0000000000009848.abstract. Acesso em 09 jun. 2020
Espinosa, P. S. et al (2020). Neurological Complications of Coronavirus Disease (COVID 19): Encephalopathy, BrainMRI and Cerebrospinal Fluid Fidings: Case 2. Dipsonível em: https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwhomdl-32499974. Acesso em 04 ago. 2020.
Gao, L., & Zhang, J. (2020). Pulmonary High-Resolution Computed Tomography (HRCT) Findings of Patients with Early-Stage Coronavirus Disease 2019 (COVID-19) in Hangzhou, China. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e923885-1
Inchiyama, T. et al (2020). Serum Cytokine Concentrations of Influenza-Associated Acute Necrotizing Encephalopathy. Pediatrics Iternational. Disponívem em: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1442-200X.2003.01822 x?sid=nlm%3Apubmed. Acesso em: 04 ago. 2020
Jiang, X., Yin, Z., Wang, T., Zhai, N., Lu, F., Zhan, C., Han, Q. e Feng, C. (2020). COVID-19 Desempenho da Tomografia Computadorizada Dinâmica (CT) e Observação de Alguns Indicadores Laboratoriais. Medical science monitor: revista médica internacional de pesquisas experimentais e clínicas, 26 , e924403. DOI: 10.12659 / MSM.924403.
Kandemirli, S. L. et al (2020). MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection. Radiology. Disponível em: https://pubs.rsna.org/doi/10.1148/radiol.2020201697. Acesso em 09. Jun 2020
Li, H. et al (2020). Use of Magnetic Resonance in the Diagnosis and Prognosis of Acute Necrotizing Encephalopathy in a Chinese Teenager. Medicine, 05 jul. 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31689857/. Acesso em: 04 ago. 2020.
Mao, L. et al (2020). Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan,China. Jamaneurology. Dipsonível em https://jamanetwork.com/journals/jamaneurology/fullarticle/2764549. Acesso em 09 jun 2020.
McGonagle, D., O’Donnell, J. S., Sharif, K., Emery, P., Bridgewood, C. (2020). Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet Rheumatol, 1-9. DOI: 10.1016/S2665-9913(20)30121-1
Phend, C. (2020). COVID-19 Pulmonary Embolism Often Seen Outside the ICU. Medpage Today. Acesso em 25 de maio de 2020 de https://www.medpagetoday.com/infectiousdisease/covid19/86535.
Poyiadji, N., Cormier, P., Patel, P. Y., Hadied, M. O., Bhargava, P., Khanna, K., Nadig, J., Keimig, T., Spizarny, D., Reeser, N., Klochko, C., Peterson, L., & Song, T. (2020). Acute Pulmonary Embolism and COVID-19. Radiology, 201955.
Wang, K., Kang, S., Tian, R., Zhang, X., Zhang, X., & Wang, Y. (2020). Imaging manifestations and diagnostic value of chest CT of coronavirus disease 2019 (COVID-19) in the Xiaogan area. Clinical radiology, 75(5), 341–347. DOI: 10.1016/j.crad.2020.03.004
Yoon, S. H., Lee, K. H., Kim, J. Y., Lee, Y. K., Ko, H., Kim, K. H., Park, C. M., & Kim, Y.-H. (2020). Chest Radiographic and CT Findings of the 2019 Novel Coronavirus Disease (COVID-19): Analysis of Nine Patients Treated in Korea. Korean Journal of Radiology, 21(4), 494. DOI: https://doi.org/10.3348/kjr.2020.0132
Yuan, M., Yin, W., Tao, Z., Tan, W. e Hu, Y. (2020). Associação de achados radiológicos com mortalidade de pacientes infectados com o novo coronavírus de 2019 em Wuhan, China. PloS one , 15 (3), e0230548. DOI: 10.1371 / journal.pone.0230548.